【摘要】 <正> 肾素—血管紧张素—醛固酮系统(RAA)与高血压发病原理密切相关。血管紧张素Ⅱ(ATII)是体内已知活性最强的缩血管物质。它还促使肾上腺皮质球状带分泌醛固酮导致水钠潴留。以上两作用均使血压升高。1976年Ondetti等首次合成了口服有效的血管紧张更多还原

【Abstract】 Captopril is a novel orally active inhibitor of angiotensin Ⅰ coverting enzyme and antihypertensive agent. In the present experiment we have found thati captopril has different effects on blood pressure in various types of stabilized hypertensive rats. Intwo-kidney Goldblatt hypertensive rats gavage of this agent lowered arterial blood pressure markedly. The effect became more marked if hydrochiorothiazide was added. In case of Skelton model addition of hydroclalorothiazide did not lower blood pressure. Captopril failed to reduce blood pressure in one-kidney Goldblatt hypertensive, rats, The mechanism of the various effects as mentioned above is worthof further research.更多还原