【摘要】 <正> 缬草(Valeriana officinalis L.)为败酱科植物缬草的根及根茎,临床用作镇静剂。近年来有人曾报道缬草对心血管系统有一定的影响。我们将天津医药工业研究所提取的缬草乙醇提取物(以下简称VES)进行了下列实验研究。 实验材料、方法及结果 将缬草用石油醚及二氯甲烷提取后,剩下不溶解的固体,再用乙醇提取,然后将乙醇蒸去,即得淡黄色粉末,称为缬草乙醇提取物,易溶于水,其水溶液称为VES。更多还原

【Abstract】 VES was the alcoholic extract of Valariana officinalis L.Intravenous injection of VES 50mg/kg to open chest anesthetized cats produced a significant increase in coronary blood flow (5.7 times over the initial value), marked decrease in oxygen consumption and heart rate, and a transient fall in blood pressure.Experiments with Langendorff’s rabbit hearts showed that on the addition of 0.1 ml of 10％ VES to infusion system the peak coronary flow was increased by 1.8 times, the heart rate was slowed by 48％ and the contractile force decreased by 45％. On adding 10％ VES 0.2 ml to the infusion system of isolated organs, the effluent flow from rabbit kidney, ear and hind limp was found to be increased 1.8、1.4 and 2 times, respectively.更多还原