【摘要】 静脉注入铃兰毒甙0.05、0.1 mg/kg和相同剂量的哇巴因,小鼠心肌对⁸⁶Rb的摄取率一致增加;剂量增大至0.25 mg/kg心肌对⁸⁶Rb摄取率变化不显著,有减少趋势;当剂量增大至0.5、1.0 mg/kg(部分小鼠引起心率失常心肌对⁸⁶Rb的摄取率一致减少。提示强心甙对冠状血管的作用与剂量有关,小剂量铃兰毒甙和哇巴因,能使小鼠心肌微血管床面积增大、心肌营养性血流量增加;中毒剂量使微血管床面积缩小、心肌营养性血流量减少。更多还原

【Abstract】 The pharmacological effects of cardiac glycosides on coronary vessels are controversial. ⁸⁶RbCI was utilized to evaluate the influences of convallatoxin and ouabain on myocardial microvascular bed.Experiments were performed on 430 mice each weighing 18-24 g. When convallatoxin was given iv 0.05 and 0.1 mg/kg, the mean ratio of myocardial uptake of ⁸⁶RbCl was significantly increased within 1 minute, reaching a peak at 15-30 minutes. The duration of elevation was more than 1 hour （table 1）. When convallatoxin was iv 0.5 and 1.0 mg/kg, arrhythmia appeared in most mice. The elevation of myocardial uptake of ⁸⁶RbCI was decreased and reached the peak at 15 minutes. Ouabain produced a similar effect.Thus, small doses （0.05 and 0.1 mg/kg） of convallatoxin and ouabain dilated the myocardial microvascular bed and increased the myocardial nutritional blood perfusion, while larger doses （0.5 and 0.1 mg/kg） of convallatoxin and ouabain yielded an opposite effect.更多还原