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人体外周血B细胞测定及其临床意义
Human Peripheral B Cell Assay and Its Clinical Significance
【摘要】 <正> B细胞具有多种表面标志,如膜表面免疫球蛋白、小鼠红细胞受体、补体C3受体和Fc受体等。目前人们认为前二种表面标志是B细胞独自具有的,因此,可用免疫荧光法和小鼠红细胞玫瑰花结试验(M-RFC)测定B细胞数量,以便判断机体体液免疫状态及其意义。在急性肾炎、系统性红斑
【Abstract】 A modified immunofluorescence method and mouse rosetteforming cell (m-RFC) assay were used to measure peripheral B cells in human controls of different age groups. The mean values measured by these methods were 10.72±1.83% and 9.19±2.44% respectively.In order to find out whether the values of B and T cells were related to certain diseases, we measured B and T cells of the peripheral blood of acute glomerulonephritis, systemic lupus erythromatosis and thyroid disease patients, with an emphasis on the glomerulonepnritis patients in whom B and T cells, total complement activity and C3 were compared before and after treatment. It was found that the mean value of B cells before treatment was very significantly increased (P<0.001), accompanied with significant reduction of total complement and C3 (P<0.01). After treatment, both values reduced to normal. The value of T cell did not show any significant change. The authors suggested that the measurement of above mentioned values is very important for the understanding of the pathogenesis, treatment and prognosis of acute glomerulonephritis and other autoimmune diseases.
- 【文献出处】 天津医药 ,Tianjin Medical Journal , 编辑部邮箱 ,1982年02期
- 【被引频次】3
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