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低血钾软病的肾小管功能观察及失钾机理的探讨

Observations of the Function of Renal Tube and theDiscussion of the Mechanism of PotassiumLoss in Hypokalemic Flabbiness Disease

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【作者】 童萼塘; 万纯臣; 陈兆聪; 胡俊德; 梅元武; 孙圣刚; 金慰鄂; 唐贵卿; 谭智明; 倪亚萍; 杜同钧; 金涛;

【Author】 Tong Etang, Wan Chunchen, Chen Zhaocong, Hu Junde,Mei Yuanwu, Sun Shenggang, Jin Weie, Tang Guiqing,Tan Zhimin, Ni Yaping, Du Tongjun, Jin Tao 1st Teaching Hospital, Wuhan Medical College, Wuhan Epidemic Prevention Station, Pingjiang County, Hunan Province Yunmeng County People’s Hospital, Hubei Province Anlu County People’s Hospital, Hubei Province

【机构】 武汉医学院第一附属医院; 湖南省平江县卫生防疫站; 湖北省云梦县人民医院; 湖北省安陆县人民医院; 湖北省安陆县人民医院;

【摘要】 <正> 近10多年来,我国部分棉产区发现一种地方性、流行性低血钾麻痹症。我们曾提出本病有类似肾小管酸中毒的改变,发病可能与肾小管受损有关,并称其为低血钾软病(以下简称软病)。为进一步探讨失钾机理,1980年对60例软病患者作了肾小管功能等检查,并以同期26例低血钾周期性麻痹(以下简称周麻)作对照。

【Abstract】 We have performed a series of examinations of renal tubular function in 60 patients with "hypokalemic flabbiness disease" (HFD) and a control group of 26 cases with periodic paralysis. The results in HFD group were all abnormal, but in the latter were all normal. In most cases of HFD. the results of ammonium chloride loading test were abnormal. The CO2 combining power of 23 patients with HFD at paralytic period was determined, 9 cases were below 41 vol%. Urine potassium of 27 patients with HFD was determined and the results of 23 were compatible with renal potassium loss. We believe that HFD may be caused by certain substance which is harmful to the renal tube and thus induces renal tubular acidosis and renal potassium loss.

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