【摘要】 在一例眼科住院病人的血红蛋白电泳检查中,发现在相当于 HbJ 的位置上有一种快速异常血红蛋白,含量为21.5%。患者虽无临床症状,但出现红细胞大小不一和血红蛋白不稳定特性。化学结构分析证明这种异常血红蛋白的氨基酸替代是α链 N 端第26位的丙氨酸变为谷氨酸[α26(B7)Ala→Glu]。这是一种新的不稳定血红蛋白,按其发现地点命名为血红蛋白沈阳(HbShenyang).更多还原

【Abstract】 This paper describes a new unstable hemoglobin found in a 23-year-old Chineseliving in Shenyang,Liaoning Province.This variant had an electrophoretic mobilityof the J type hemoglobin and amounted to 21.5% of the total hemoglobin.No clinicalmanifestations were observed except mild hematological changes.Structural studies ofthe variant showed that the alanyl residue in the 26th positon of α-chain is substi-tuted by glutamyl residue and the hemoglobin may be represented as α26(B7)Ala→Glu.This variant was thus named hemoglobin Shenyang after the city where it was firstfound.The α26 alanyl residue is an internal and partly visible amino acid residue;thesubstitution of Glu for Ala might influence the stability of the hemoblobin molecule.更多还原