【摘要】 小鼠胚胎、新生和成年小鼠肝脏,都含有一种在体外能抑制小鼠淋巴细胞增生的因子。此因子无品系特异性,能抑制H-2单型相同或不同的淋巴结或脾细胞对植物血凝素(PHA)、刀豆素A(ConA)、大肠杆菌脂多糖(LPS)和混合淋巴细胞培养诱发的淋巴细胞增生。这表明肝脏抑制因子既能抑制T细胞又能抑制B细胞对促有丝分裂原和同种异型抗原刺激所致的应答反应。此因子的抑制作用强烈,在使用浓度时,这种抑制作用是可逆的,一旦洗去肝浸液,淋巴细胞就恢复正常的应答功能。 在肾脏未观察到抑制淋巴细胞增生因子,而脾脏含有比肝脏较弱的抑制因子。更多还原

【Abstract】 It has been shown that cell-free liver-extract from embryonic, newborn and adult mice livers contains a factor which can suppress in vitro the proliferative response of splenic and lymph node lymphocytes to mitogens (phytohemagglutinin, PHA; concanavalin A, Con A; lipopolysaccharide, LPS) and allogeneio antigens. The immunosuppressive activity of this factor was nonstrain-specific since the sup-pressive action on the response of lymphocytes from the donor mice and other strains as well was effective. Eesults showed that the factor induced suppression of the proliferative response of both T-cell and B-cell to mitogens and allogeneio antigens. This immunosuppressive action was found to be reversible; as the liver extract was eluted from the medium, the response of lymphocytes returned to normal. The sup-pressive effect was not seen in experiment with kidney-extract, but a slight effect was shown with spleen-extract.更多还原