【摘要】 本文概述了在白细胞分型研究中数学方法和电子计算机应用软件的重要性,并提出我国自行研制的用于白细胞分型研究的一个应用软件系统,其主要内容和功能为: ①HLA-SA-1聚类分析程序。②HLA-SA-2血清图绘制,抗原指定及后验概率计算程序。③HLA-SA-3血清特异性鉴定程序。④HLA-SA-4遗传参数(包括抗原频率,基因频率,双位点单倍因频率,连锁不平衡参数)及其方差计算程序,⑤HLA-SA-5疾病相关研究中的抗原关联分析及单倍型关联分析程序。⑥HLA-SA-6群体研究中遗传距离分析程序。这些数学方法及计算程序经各单位用于人体和猪白细胞分型实验数据的处理均获得满意结果。更多还原

【Abstract】 This paper outlined the importance of mathematical methods and computer softwares in the study of leukocyte typing and presented the corresponding software package. Six programs included in this system are as follows:1. HLA-SA-1 Program for clustering analysis. 2. HLA-SA-2 Program for serograph analysis antigen assignment and calculation of posterior probability.3. HLA-SA-3 Program for identication of ferum specificities.4. HLA-SA-4 Program for calculation of genetic parameter and corresponding variances.5. HLA-SA-5 Program for antigen and haplotype association analysis in HLA and disease study.6. HLA-SA-6 Program for calculation of various parameters of genetic distance in population studies.These methods and softwares have been used in the treatment of experimental data of human and swine leukocyte typing. Satisfactory results were obtained.更多还原