【摘要】 本实验用成年雄性家兔38只,分为胃溃疡实验组和对照组。实验组用少量冰醋酸注入胃粘膜下层,造成实验性胃溃疡。对照组分盐水对照组,即用生理盐水注入胃粘膜下层,模拟手术;空白对照组,不做手术。手术后3～49天之内,分批取肾上腺,进行组织化学观察。在实验性胃溃疡期间,肾上腺皮质的组织化学变化以束状带和网状带比较明显。在胃溃疡手术后早期,束状带和网状带充满嗜苏丹黑B脂类小滴,并充满用Schultz氏法显示的胆固醇小滴,随后,脂类和胆固醇小滴减少。抗坏血酸稍减少,随后稍增多。琥珀酸脱氢酶的活性稍增强。这些变化在胃溃疡手术后10天之内比较明显,14天开始恢复,18天以后逐渐恢复正常。在盐水对照组于手术后早期,即出现束状带和网状带的脂类和胆固醇减少,抗坏血酸稍增多,琥珀酸脱氢酶的活性稍增强。以上变化在手术后3天比较明显,10天开始恢复,14天以后恢复正常。讨论了以上组织化学变化的意义,并提示在实验性胃溃疡期间,还存在内分泌调节途径。更多还原

【Abstract】 Thirty eight adult male rabbits were selected for the experiment. The experimental peptic ulcer was induced by means of injection of 40% acetic acid to the submucosa of the stomach. Animals of the control group were injected with normal saline instead and another control group consisted of normal rabbits without any treatment. The animals were killed by decapitation at different time intervals (3～49 days) after the operation. The adrenal tissues were prepared for histochemical studies from both experimental and control animals. The results were observed as follows:During the early stage of the peptic ulcer, the fascicular and reticular zones were the chief sites in the adrenal cortex where histochemical changes were involved. Three days after the peptic ulcer operation, the cells of the fascicular and reticular zones filled with sudanophilic lipid droplets and cholesterol droplets. Five days after the operation, both of lipid droplets and cholesterol droplets decreased; the content of ascorbic acid increased slightly; and the activity of succinic dehydrogenase also increased. The above changes were most conspicuous in the inner portion of the fascicular zone within ten days. After fourteen days, all the above histochemical changes began to recover and gradually returned to the normal level after eighteen to thirty five days. In the normal saline operation control group, the contents of lipid droplets and cholesterol droplets decreased in the fascicular and reticular zones after three days and returned to normal level during the period of ten to fourteen days after operation for saline injection.The above histochemical changes showed that the adrenal cortex was at an active functional state during the early period of the experimental peptic ulcer.更多还原