【摘要】 <正> 1972年Addison等建立血清铁蛋白的免疫放射分析法,1974年Niitsu等又建立了放射免疫分析法并在临床上得到广泛应用。认为血清铁蛋白能反映体内贮备铁总量,是检测机体铁营养状态、缺铁及铁负荷过度的有效指标;有助于缺铁性贫血和铁利用障碍性贫血的鉴更多还原

【Abstract】 A method for the measurement of serum ferritin by radioimmunoassay is presented. Ferritin was isolated from human liver. 125I-labelled human liver ferritin and rabbit antiferritin antibody were prepared. Goat anti-rabbit gamma globulin antibody, together with polyethylene glycol, was used as the separating reagent. The working range was up to 320ng/ml. The method was simple to handle, precise, and sensitive, and it was therefore thought to be suitable for routine diagnostic measurement of ferritin. Serum ferritin values for groups of men, women, and women older than 50 years were 104.3±5.8, 30.5±1.7 and 64±6.8 ng/ml respectively (x±E). The blood donors from rural areas had much lower values. Eight of ten patients with iron deficiency anemia had significantly lower values (<5.4ng/ml). Ferritin concentrations were greatly increased in three patients with acute myelo-cytic and promyelocytic leukaemia.更多还原