【摘要】 <正> 人类核仁形成区(NOR)位于5对近端着丝粒染色体的副缢痕处,也是人类18S—28S rRNA 基因所在的位置。近几年通过银染技术能使 NOR 特异染色,并且证实只有在功能上有活性的NOR 才能被银染,因此银染技术被认为是目前探讨 rRNA 基因功能的准确方法。更多还原

【Abstract】 Using the method of Ag-Ⅱ staining,we studied on NORs and Acro- centries association in 13 women having taken oral contraceptive“Tablet Norethindroni Compositae”for a long term and in 13 women having taken no contraceptive,as controls. The distribution of the Ag-stained NORs(Ag-NORs),the Ag-stained associated acrocentric chromosomes(Ag-AAC)and the Ag-stained acro- centrics associations(Ag-AA)in Tab.Users and Controls were randomizing in Denver Group Level. The similar modal and the frequency of Ag-NORs in both groups suggested that“Tablet Norethindroni Compositae”had no effect on the numbers of the active rRNA gene. The mean number of Ag-AAC per cell and that of Ag-AA per cell were less in Tab.Users than in Controls.There was significant difference between Tab.Users and Controls.This suggested that“Tablet Norethin- droni Compositae”might decrease the activity of rRNA gene in women taking the drugs,and that women taking the drugs did not run the risk of the birth of the child with trisomy or translocation.更多还原