【摘要】 本文报道采用血清EB病毒VCA—IgA抗体检测法检测放疗前后鼻咽癌病人、其他恶性肿瘤病人、非癌疾患病人以及正常人共532例。证明此法对鼻咽癌的诊断具有较高的特异性,且有早期诊断的价值。同时进行血清紫色反应检测不仅能提高鼻咽癌诊断的阳性率,还具有监测病情变化与观察疗效的作用。更多还原

【Abstract】 A total of 532 sera from patientswith nasopharyngeal carcinoma (NPC),patients with other malignancies,patients with non-malignancies of headand neck and healthy normal controlswere tested for IgA antibody to theviral capsid antigen(VCA) of Epstein-Barr virus (EBV)by indirect immuno-fluorescence test.93. 57% of 140 untreatedNPC patients had IgA antibody to VCAwith geometric mean titer (GMT) of1: 16. 80. No antibody could be foundin sera from 114 normal controls and9 patients with other malignancies.The positive percentage and GMT ofIgA antibody to VCA in the otherpatients were much lower than in thoseof NPC patients. Among 140 untreatedNPC patients, the positive percentageof IgA antibody to VCA showed nocorrelation with clinical stage. How-ever,the GMT of IgA antibody to VCAshowed a progressive increase withincreasing tumor stage.The GMT levelof IgA antibody to VCA declinedgradually with an increase in survivaltime among 31 treated NPC patientsafter 1 week to 12 years, whereas itincreased in 21 treated NPC patientswho had recurrence or distant metastasisafter 6 months to 14 years. The optical density(OD)mean valueof purple colorimetric response in pa-tients with stage I tumors and nonma-lignancies had no significant differencefrom those in normal subjects. However,the positive percentage and OD meanvalues of purple colorimetric responsewere greater in patients with stage Ⅲand Ⅳ tumors than in those with stage1 and Ⅱ tumors(p<0.01). The positivepercentage and OD mean values of purplecolorimetric response were greater inthose with recurrence or distantmetastasis than in survival treatedpatients. So the findings demonstratedthat measurement of serum IgA antibodyto EB virus VCA and purple colorimetricresponse are useful in serodiagnosis andmonitoring of response to treatment ofnasopharyngeal carcinoma.更多还原