【摘要】 本文观察甲地孕酮15mg、戊酸雌二醇5mg之复方微囊注射液的避孕效果:在433例育龄妇女、5351周期中妊娠率为0.88％,而无微囊者妊娠率为6.03％。用药1～2年者未见对血压之影响及乳癌、宫颈癌患者。31例用药者血糖,52例血脂等检查与对照组正常妇女值相同。31例子宫内膜光镜及6例电镜检查显示以黄体影响占优势。3例妇女内分泌周期测定证实该药抑制排卵。更多还原

【Abstract】 A clinical and laboratory studywas carried out to determine the fea-sibility of microencapsulated compoundmegestrol acetate as an intramuscularcontraceptive. The total of 433 womenwere studied for more than two yearswhile receiving monthly intramuscularinjections of a microencapsulated com-pound consisting of megestrol acetate15 mg and estradiol valerate 5mg. Inall, a total of 5351 periods was obser-ved. The average number of periodswas 12 cycles for all users. The inci-dence of side effects, such as gestroin-testinal disturbance and headache, wasvery low, because the contraceptiveconsisted of the lower dosage of thesteroids required in microencapsulation.The pregnancy rate per 100 women’syears was 0.88. However, when themicrocapsular coat of the contraceptivewas dissolved, the pregnancy rate ofusers was increased. The rate of break-through bleeding in the total numberof peroids was 2.03%. The blood pres-sure of the subjects who had used thecontraceptive for 1-2 years remainednormal. Clinical examinations forbreast tumor and cervical malignancywere negative. The data of 52 womenshowed no changes in serum cholesteroland triglyceride. The glucose tolerancetest in 31 women revealed normal cur-ves. The estrogen and pregnandiolcontent of the urine were estimatedin 3 women before and after adminis-tration of contraceptive. The resultsshowed that the microencapsulatedagent prevented ovulation. Pathologicstudy of the endometrium, 31 casesunder light microscopy and 6 casesunder electron microscopy, revealedsignificant structural changes due tothe effects of progesterone, suggestingno possibility of implantation of ovum.更多还原