【摘要】 本文使用姊妹单体交换法证明抗霉毒剂 HD 处理后的黄曲霉毒素 B₁不具有致突变性。更多还原

【Abstract】 It has been reported that aflatoxin B₁（AFB₁）treated with antimycotoxin—HD lost its fluorescence and the special pathogenetic effect on new born ducklings.In order to evaluate the mutagenicity of AFB₁ treated with antimycotoxin—HDsister chromatid exchanges（SCE_S）were examined in Chinese hamster cells exposedto concentrations of 0.01,0.02,0.04 and 0.06μg/ml of both antimycotoxin—HDtreated and untreated AFB₁The result confirmed that there was a linear dosere-sponse relationship betweenthe frequency of SCE and the concentration of untreated AFB₁ from 0.02—0.06μg/ml with a correlation coefficient of 0.88 and a regression line Y=5.26+114.66x.On the contrary,frequency of SCE induced by AFB₁ treated with antimycotoxin—HD lost the above-mentioned dose-response relationship and with a flattened reg-ression line（Y=4.98+2.45x）and the correlation coefficient is 0.08.The differencebetween the two regression coefficients is highly significant（P<0.001）,It is concludedthat the mutagenicity of AFB₁ has been nullified by the treatment of antimycoto-xin—HD.更多还原