【摘要】 <正> 关于3-氯丙二醇及2,3-氧丙醇的抗生育作用曾多次被证实,它们主要作用于副睾,影响精子受精能力,具有避孕起效快、恢复快的特点,但由于副作用还存在,未能运用于临床。据本文作者的报道,二者合并用药有减少单独用药量及副作用,并保持其原有避孕效果的作用。并提出3-氯丙二醇5 mg/kg/天×2加2,3-氧丙醇75mg/kg/天×2有较满意的抗生育效果,有效避孕天数多在14天左右,最少的避孕天数是10天。更多还原

【Abstract】 The combined daily dose of 5mg/kg of a-chlorohydrin and 75mg/kg of glycidol were orally administered for 2 consecutive days to the male rats. These animals received this course of treatment once every 10 days for three ten-day periods. The antifertility was assessed by the number of implantations in mated females. During the experimental period of 30 days, all of the treated animals were sterile. After the third ten-day period,the recovery time of fertility varied from 13 to 17 days. However, in some animals, fertility was not recovered until 107 days after the third ten-day period. According to histological examination, there was damage to the spermatogenesis in the testes of these animals. Except a few animals with hepatocytes persisting mild swelling degeneration, no recognizable pathological changes in other inner organs of the treated animals could be found. The ability of mating was not affected by the treatment. It is suggested that a consecutive course of treatment with a low combined dose of a-chlorohydrin and glycidol can produce sterility in male rats lasting a longer time without affecting the libido and without obvious damage to the inner organs of the treated animals.更多还原