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在冰醋酸溶液中L(+)-伪麻黄碱的异构化
A STUDY ON ISOMERIZATION OF L( + )-ψ-EPHEDRINE IN GLACIAL ACETIC ACID
【摘要】 在冰醋酸溶液中,L(+)-伪麻黄碱可以异构化成D(-)-麻黄碱。氧化铝薄层层析结果表明:在反应液中存在N-乙酰L(+)-伪麻黄碱,N-乙酰D(-)-麻黄碱和一种未鉴定结构的化合物,并初步推出可能的异构化机理。 5—10%L(+)-伪麻黄碱的冰醋酸溶液,回流反应20小时,立即回收醋酸后,用2.5/V的氢氧化钠溶液进行水解,再通过草酸盐变为盐酸盐即得。以L(+)-伪麻黄碱计纯盐酸D(-)-麻黄碱收率达31.2%。
【Abstract】 L( + )-ψ-ephedrine could be isomerized to D(-)-ephedrine in glacial acetic acid. The method of isomerization was rather easy as follows:A 5% solution of L( + )-ψ-ephedrine in glacial acetic acid was refluxed for twenty hours, then acetic acid was removed immediately from the mixture under diminished pressure. The residue was hydrolyzed with 2.5 N NaOH solution. The D( - )-ephedrine oxalate was first prepared from the product of hydrolyzation and finally converted to its hydroehloride. The yield of pure product was about 31.2% of the theoretical based on the L(+ )--ephedrine.
- 【文献出处】 高等学校化学学报 ,Chemical Research In Chinese Universities , 编辑部邮箱 ,1982年03期
- 【被引频次】4
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