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氚水诱发人体外周血淋巴细胞染色体畸变及其剂量-效应关系

THE CHROMOSOME ABERRATION IN HUMAN PERIPHERAL BLOOD LYMPHOCYTES INDUCED BY TRITIATED WATER IN VITRO AND ITS DOSE—RESPONSE

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【作者】 冯嘉林邵松生刘红珍邹美君林雅萍要福增吴元芳高秀芳

【Author】 Feng Jialin;Shao Songsheng;Liu Hongzhen;Zou Meijun;Lin Yaping(Shanghai Industrial Hygiene Institute)Yao Fuzeng;Wu Yuanfang;Gao Xiufang(Shanghai Institute of Atomic Nucleus,Academic Sinica)

【机构】 上海市工业卫生研究所中国科学院上海原子核研究所中国科学院上海原子核研究所

【摘要】 将人体外周血在不同剂量的氚水中培养54小时,观察到淋巴细胞第一次有丝分裂中期的染色体型及单体型畸变。试验表明氚水浓度在0.5微居里/毫升以上时,这两种类型的畸变均有随氚浓度的增高而增加的趋势,并与浓度存在一定的依赖关系。用幂函数计算适合度最好。当氚浓度低于0.5微居里/毫升时,则畸变与氚浓度之间未见规律性的相关。

【Abstract】 Human Peripheral blood exposed with tritiated water at variousdoses for 54 hr was examined to observe the chromosome and chromatid abe-rrations at metaphases in the first mitosis of lymphocytes.The findings indi-cate that above 0.5μCi/ml of tritiated water,a tendency to increased aberrati-on yield in both types with increasing of tritium concentration and a dose-dependency can be seen and the aberration yield is best fitted by the exponentialfunction.No regular relation between aberration yield and tritium concentr-ation was found below 0.5μCi/ml of tritiated water.

  • 【文献出处】 辐射防护 ,Radialization Protection , 编辑部邮箱 ,1982年02期
  • 【被引频次】3
  • 【下载频次】16
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