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氚水诱发人体外周血淋巴细胞染色体畸变及其剂量-效应关系
THE CHROMOSOME ABERRATION IN HUMAN PERIPHERAL BLOOD LYMPHOCYTES INDUCED BY TRITIATED WATER IN VITRO AND ITS DOSE—RESPONSE
【摘要】 将人体外周血在不同剂量的氚水中培养54小时,观察到淋巴细胞第一次有丝分裂中期的染色体型及单体型畸变。试验表明氚水浓度在0.5微居里/毫升以上时,这两种类型的畸变均有随氚浓度的增高而增加的趋势,并与浓度存在一定的依赖关系。用幂函数计算适合度最好。当氚浓度低于0.5微居里/毫升时,则畸变与氚浓度之间未见规律性的相关。
【Abstract】 Human Peripheral blood exposed with tritiated water at variousdoses for 54 hr was examined to observe the chromosome and chromatid abe-rrations at metaphases in the first mitosis of lymphocytes.The findings indi-cate that above 0.5μCi/ml of tritiated water,a tendency to increased aberrati-on yield in both types with increasing of tritium concentration and a dose-dependency can be seen and the aberration yield is best fitted by the exponentialfunction.No regular relation between aberration yield and tritium concentr-ation was found below 0.5μCi/ml of tritiated water.
- 【文献出处】 辐射防护 ,Radialization Protection , 编辑部邮箱 ,1982年02期
- 【被引频次】3
- 【下载频次】16