【摘要】 本文究研了Thio-TEPA对家蝇卵子发生的影响,描述了Thio-TEPA引起卵巢发生的细胞病变。主要的改变发生在卵原区与第一卵室中。在卵室中,滤泡细胞改变最大,营养细胞次之,卵母细胞影响最小。由各种病变的情况——染色质的疑聚与固缩,细胞泡化及肥大等——讨论了Thio-TEPA可能的作用机制。 1963年,我们在筛选中发现Thio-TEPA对家蝇有十分显著的不育性效果,后来实验证明Thio-TEPA对其他昆虫也有效(张宗炳、曹泽溥等1963;张宗炳、姜水嘉 1964)。这里我们报导了Thio-TEPA对家蝇卵子发生引起的细胞病变,企图由此说明Thio-TEPA造成不育的作用机制。更多还原

【Abstract】 The present paper is a report on the effect of Thio-TEPA on the oogenesis of the common housefly, Musca domestica vicina. Histo-pathological changes chiefly in the gcrmarium, and only one egg chamber was formed in each ovariole. Follicular cells in the egg chamber were severely disranged and chro-matin condensation could be frequently observed, followed by pycnotic changes in the nucleus and vacuolation of the cytqplasm. Similar changes occurred in nutritive cells, but to a lesser extent. The oocytc was least alfcctcd, the only pathological change was reduction of size and failure to develop beyond 6th stage. This was possibly due to lack of supply of nutritive substances from the follicular and nutritive cells. It seems therefore that cells in active mitotic division were most easily affected. The mode of action of Thio-TEPA in causing sterility in the female housefly was discussed in relation to these pathological changes,更多还原