【摘要】 <正> 带瘤机体包括人和动物,在其癌性腹水和血清中存在一种对免疫系统具有很强抑制作用的物质,叫免疫抑制物或免疫抑制因子。这种体液因子,显著地抑制淋巴细胞免疫反应。这已被大量实验所证实。据Whittaker等人(1971)报告,进行性乳癌患者淋巴细胞,在患者自身血清培养条件下,淋巴细胞转化率为27.5％。如培养在正常人血清中,转化率可以上更多还原

【Abstract】 An immunosuppressive factor was extracted from mouse cancer ascites. The factor shows a strong suppressive effect on the function of antibody-formation cell and of macrophage. The highest suppressive effect was observed at seventh day after injection 0.5 ml of the factor (ip) into normal mouse and then the effect disappeared or decreased to lower level at eleventh day. The suppressive effect was so strong that the factor corresponding to 0.004 ml of raw material could cause 55% deppression of the immune function.There were several fractions separated by column chromatography on Sephadex G 75. Three fractions, the Kav values of which were at 0.13-0.14, 0.19 and 0.27-0.56, appeared to show obvious effect on AFC. The other five fractions, the Kav values of whieh were at 0.071,0.13-0.14, 0.19, 0.27-0.28 and 0.39-0.56, deppressed the phagocytosis of macrophage.更多还原