【摘要】 <正> 膀胱癌病因研究中,在化学致癌方面,以职业性芳香胺类致癌的研究最多,历史亦最长,并获得肯定的结论。与此有联系的是内源性色氨酸代谢异常,导致尿中芳香胺类代谢产物增加及其与膀胱癌关系的研究,五十年代后期开始有人注意到吸烟可使肺癌与膀胱癌的发病同时升高,对这个问题的探更多还原

【Abstract】 A retrospective epidemiological investigaton was made on 334 cases of bladder can-cer about thier occupational histories and smoking habit. All of the patients were emplo-yees of the Shanghai Industry-Communication System and Finance-Trade System whohad survived up to August 1978. Persons without bladder cancer were chosen from the same district as control groupand matched as to age and sex with the cancer group. People who had worked in dye-stuff, rubber, electric cable or tobacco industries for more than half a year were reg-arded as having occupational exposure. A study of the pair-matched data showed that occupational exposure and smokinghabit were significantly related to the morbidity of bladder cancer and the relationshipof cancer to occupational exposure was more significant than to smoking habit. Among the 315 male patients, 12.9% had occupational exposure, most of thembeing dyestuff workers. The results suggested that occupational exposure may be an im-portant factor in the pathogenesis of bladder cancer in Shanghai.更多还原