【摘要】 <正> 近年来国内外对肝癌病因进行大量的调查研究。许多资料表明,肝癌的主要病因可能有黄曲霉毒素、肝炎病毒、亚硝胺和遗传因素等。不少作者认为,肝癌是多种因素综合作更多还原

【Abstract】 Among 109 members compoing four generations in a liver cancer family, tsuffered from this type of cancer, Seven directly-related members of the proband were examinedfor sister hromatid exchange (SCE) and nine unrelated individuals living in the same village were chosen as control. Spontaneous SCEs of cultured peripheral blood lymphocytes from the two groups showed no difference (F= 0.91,P>0.20). After the lymphocytes were treated with aflatoxin B1 (AFB1) 0.001ug/ml, increased SCE-s were observed in lymphocytes from members of the liver cancer family, being higher than that of the control(F=15.06, P<0.001). Routine assay for AFP, HBsAg and SGPT was also performed and none of them was positive. Neither were the differences in chromosomal breaks, polyploidy, mitotic indices. The possibility that high risk individuals predisposed to cancer might express their genetic susceptibility only under the strain of carcinogens was discussed.更多还原