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服用甾体激素避孕药后分娩子代与母亲染色体分析

An Analysis on Lymphocytic Chromosome of Women Administered with Oral Steroid Contraceptive and Their Filial Generation

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【作者】 周健仪苏雪芳李坚林婵珠

【Author】 Zhou Jianyi Su Xuefang Li Jian Lin ChanzhuDirector: Liang Guishang(Gynaecological Laboratory, First Affiliated Hospital, Zhong Shan Medical College)Family Planning Research Institute of Guangdong

【机构】 中山医学院第一附属医院妇产科实验室广东省计划生育研究所广东省计划生育研究所

【摘要】 <正>甾体激素长效口服避孕药在临床上使用越来越广泛。停药后再度妊娠,对子代有无影响,国外学者仍有不少争论。国内文献报道不多。为此,我们自1977年始对曾服长效复方18甲基炔诺酮避孕药(简称复方18甲)的妇女,停药后及其妊娠分娩的子代进行淋巴细胞染色体培养分析。

【Abstract】 In order to find out if there is a hereditary response in the filial generation whose mother has been administered with steroid contraceptive we selected 20 women on longterm methylnorethindrone Co. ( in full and low dosages) and 25 cases of their filial generation and analysed the lymphocytic chromosomes in their peripheral and umbilical blood in contrast with 13 cases of uuadministered womens normal filial generation, 24 unadminis tered women and 16 administered and non-pregnant women.We found that the chromosome aberration (C A) rate of the filial generation to be respectively 0.26% in administered group and 0% in normal group, showing no significant difference in C A But in the administered women C A there seemed to be some difference in the C.A.between those in full dosage and those with lower dosage: 0.86 V S 0%. As to the contrast groups: in the non-pregnant group the C A was 0.30% in the group administered in full dosage and 0.33% in the group in lower dosage. While in the unadminis tered group it was 0.46%.Among the cases of filial generation with no C A detected on regular analysis 4 samples were taken at random for analysing the G-ba-nding of chromosome and one of their was revealed to have fragment defect phenomenon of chromosome.

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