【摘要】 <正>穿心莲,学名Andrographis paniculata Ness.为爵床科(Acanthaceae)穿心莲属一年生草本植物,又名一见喜,榄核莲,印度草,苦胆草。原产热带、亚热带地区,喜温暖、向阳和湿润环境,我国南方各省都可栽培。有清热、解毒,消炎等功用。所含几种主要成分均属内酯类。 广东省梅县地区人民医院用穿心莲提取物治疗恶性滋养叶肿瘤有效。但抗瘤有效成分未明,所用的氯仿提取物难溶于水,妨碍配成含量恒定的注射制剂,影响疗效的稳定性。因此必须分离和确定穿心莲抗恶性滋养叶肿瘤细胞的有效成分,通过实验研究,找出抗滋养叶细胞作用的根据。尤其希望制取有效成分的水溶性制剂,方便应用,并保证制剂的含量。抗滋养叶细胞的成分除可用于抗绒癌外,亦可能用于终止早,中期妊娠。更多还原

【Abstract】 It is shown that extracts from Andrographis paniculata possesses definite therapeutic effect on human trophoblastomas. A component called M-4 was prepared for experimental and preliminary clinical tests, which was extracted with chloroform from the alcoholic infusum of the whole leaf of Andrographis paniculata after partial isolation of Andrographolide. It was shown that adminstration of M-4 through a stomach tube to the rabbits, starting on the 13th pregnant day, for 4-6 days; would kill all the. fetus The villi of the placenta showed degeneration and necrosis, microscopically. In the W-256 carcinosarcoma system in rats, M-4 showed marginal activity with the inhibition rate of tumor growth about 25%. Considering the main principles contained in M-4, the dehydroandrographolide succinate, called Androgr. -4, was prepared. Under the dosages of about 300mg/kg/ D, Androgr. -4 induced 37-64% inhibition of growth of W-256. When 200mg/kg/D of Androgr-4 was injected intravenously to female rabbits, starting on the 8th pregnant day, for 10 days, allthe fetus of the rabbits died and were necrotized.The aforementioned results of the experiments showes, that preparations of Andr-ographis paniculata posseses anti-trophoblastic activities. They can kill the fetus when used in the early or middle stage of pregnancy. This may be of use to terminate pregnancies for the purpose of family planning. Although W-256 of the rats is not a good animal model for human choriocarcinomas, it can be shown that Androgr-4 possesses definite antitumor activity.更多还原