【摘要】 <正> 臭牡丹(Clerodendron bungei steud)系马鞭草科赪桐属植物。民间用其治疗脱肛、跌打等。广西隆林县妇幼保健站用于治疗子宫脱垂,疗效较好。广西医药研究所周沛春等从臭牡丹中提取分离得总生物碱及乳酸镁,临床证明有治疗子宫脱垂作用。我们以家兔子宫圆韧带肌电为指标,观察臭牡丹对该肌电的影响及其机制,以阐明臭牡丹治疗子宫脱垂作用机更多还原

【Abstract】 A decoction of Clerodendron bungei steud, its total alkaloids and magnesium lactate were found to be efficacious in treating prolapse of uterus. This paper reports their effect on electromyogram of ligament teres uteri in rabbit.The experiment has been carried out in seventy-one adult female rabbits anaesthetized with 0.5g/kg of urethan i. v. The change of electromyogram of the left ligament teres uteri was recorded with unipolar electrode conduction. Intravenous injections of decoction of Clerodendron bungei steud, its total alkaloids or magnesium lactate in doses of 15 g/kg, 45 g/kg and 27 mg/kg, respectively, were able to increase the strength of the electromyogram of ligament teres uteri in rabbits Noradrenaline was shown to have the same effect. This action can be blocked by previous injection of regitin iv, but not by propranolol. This result indicates that α-adrenergic receptor appears to increase the electromyogram of ligament teres uteri in rabbits. The total alkaloids and magnesium lactate which increase electromyogram of ligament teres uteri in rabbits may be relevant to the stimulation of the α-adrenergic receptor. Thus, one of the mechanisms of the effect of Clerodendron bungei steud on prolapse of uterus is likely to restore and increase the ligament tone.更多还原