【摘要】 <正> 我们于1965年首次把杀昆虫药溴乙酸正十六烷酯用于防治小鼠日本血吸虫病的研究,获得显著效果,同时发现溴乙酸钠亦有50％以上的减虫串。鉴于有关这方面的研究未见文献报道,为此,我们合成了一系列溴乙酸酯类供筛选,并合成了其他相应的化合物供防治比较研究。 合成的化合物类型有:更多还原

【Abstract】 We first found that monobromoacetates were active against Schistosoma japonicum.A series of monobromoacetates was prepared and screened for antischistosomal activity. Many of these compounds were found to possess pronounced activity against Schistosoma japonicum both in mice and in dogs.The compounds with a parasite reduction rate exceeding 90% were as follows:The following compounds were shown to possess 100% prophylactic effect against schistosomal infection.更多还原