【摘要】 <正> 5-甲基-3-磺酰胺基异(口恶)唑是长效性磺胺药,其重要中间体5-甲基-3-氨基异(口恶)唑(Ⅱ)是通过5-甲基异(口恶)唑-3-甲酰胺(Ⅰ)经Hofmann反应来制备的。更多还原

【Abstract】 3-Garbamoyl-5-methyl-isoxazole (Ⅰ) reacts with aqueous sodium hypochlorite solu-tion to give 5-methyl-3-aminoisoxazole (Ⅱ) through the Hofmann rearrangment. In this reaction a new by-product is observed and is shown to be 5,5’-dimethyl-3, 3’-azo-isoxazole (Ⅲ) by chemical methods and spectral analyses.It is possible that the by-product (Ⅲ) produced is due to the presence of excess of sodium hypochlorite which oxidizes amino-product (Ⅱ) to azocompound (Ⅲ).更多还原