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5-甲基异(口恶)唑-3-甲酰胺的Hofmann反应

THE HOFMANN REACTION OF 3-CARBAMOYL-5-METHYLISOXAZOLE

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【作者】 李云贵马灵台王序

【Author】 Li Yungui, Ma Lingtai and Wang Xu (Department of Pharmacy, Beijing Medical College)

【机构】 北京医学院药学系北京医学院药学系

【摘要】 <正> 5-甲基-3-磺酰胺基异(口恶)唑是长效性磺胺药,其重要中间体5-甲基-3-氨基异(口恶)唑(Ⅱ)是通过5-甲基异(口恶)唑-3-甲酰胺(Ⅰ)经Hofmann反应来制备的。

【Abstract】 3-Garbamoyl-5-methyl-isoxazole (Ⅰ) reacts with aqueous sodium hypochlorite solu-tion to give 5-methyl-3-aminoisoxazole (Ⅱ) through the Hofmann rearrangment. In this reaction a new by-product is observed and is shown to be 5,5’-dimethyl-3, 3’-azo-isoxazole (Ⅲ) by chemical methods and spectral analyses.It is possible that the by-product (Ⅲ) produced is due to the presence of excess of sodium hypochlorite which oxidizes amino-product (Ⅱ) to azocompound (Ⅲ).

  • 【文献出处】 药学学报 ,Acta Pharmaceutica Sinica , 编辑部邮箱 ,1981年03期
  • 【被引频次】1
  • 【下载频次】94
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