【摘要】 文中介绍收治肾病综合征115例。82例单独用强的松治疗的患儿中58例完全缓解。完全缓解率为70.7％,如将部分缓解的病例包括在内,则总的缓解率为85.4％。但是这组的复发率高,41例随访病人中有29例复发,复发者的平均缓解期为3.23月,复发率为70.7％。其余12例平均随访13.96月未复发。 37例强的松治疗无效或激素依赖或强的松治疗后复发的病人,采用环磷酰胺加小剂量强的松治疗,其中27例完全缓解(73％)。总的缓解率(包括部分缓解在内)为86.5％。随访31例,其中8例复发,复发者平均缓解期为11.4月。其余23例平均随访15.3月未复发,复发率为25.8％,环磷酰胺组的复发率较强的松组为低,统计学上具有显著性(P<0.01),比较两组复发者的缓解期和未复发者的随访期表明,环磷酰胺组的缓解期比强的松组明显延长(P<0.01)。更多还原

【Abstract】 58 out of 82 patients treated with prednisone alone completely remitted (remission rate 70.7％). However, the relapse rate in this group was high. 29 out of 41 patients followed up for a mean period of 3.2 months relapsed (relapse rate 70.7％). The other 12 cases had remained in remission for a mean period of 14 months follow up. 37 patients who were non-responsive to or developed dependence on prednisone or relapsed from prednisone alone were treated with cyclophosphamide in addition to small doses of prednisone. 27 of these patients completely remitted(73％). 8 out of 31 patients relapsed after a mean period of 11.4 months, while the remaining 23 patients persisted in remission for a mean period of 15.3 months. The relapse rate was 25.8％, being much lower than that in the prednisone group (p<0.01). A comparison between the durations of remission in relapse cases and the periods of follow-up in non-relapse cases for both groups shows that remission in the cyclophosphamide group persisted longer than that in the prednisone group (P<0.01).更多还原