【摘要】 <正> 按照祖国医学理论,针刺作为外因,通过体内调节系统实现各种治疗作用,针刺镇痛则是通过加强和激活体内痛与抗痛调节系统而凑效.以往工作纳洛酮能大部分阻断针刺抑制内脏痛反应,说明内源性吗啡样物质包括在体内抗痛系统内而参与针刺镇痛作用.国内外研究吗啡镇痛作用时,发现室周一导水管周围灰质(PAG)是吗啡的高效区,电刺激脑干某些区,特别是中脑更多还原

【Abstract】 Recent experiments have demonstrated that serotonin,as a neuro-transmit-ter,is involved in acupuncture analgesia and that NRM plays an importantrole in the descending inhibitory control on nociceptive information,In ourpresent study the role of NRM in acupuncture anti-visceralgia was investi-gated.Experiments were performed on male,awake and restrained rats.Elec- trolytie lesions(0.8=1.0mA, 8-10 sec.)of NRM were made using a 0.5mmexposed tip electrode inserted stereotaxically into NRM 5-7 days beforeexperimentation.Analgesia testing was carried out with splanchnic nocicep-tire defensive reflex measured by induced abdominal muscle discharge.It was found that antivisceralgia produced by electro-acupuncture(EA)was markedly reduced in the lesion rats whereas the effects of EA was stillsignificant in sham lesion rats.In addition,NRM central stimulation delivered through an implantedconcentric electrode with 100μA constant current could produce similar anti-visceralgia effects as EA.These results show that NRM activated by EA plays an important rolein producing antivisceralgia.The possible correlation between the endogenousopiate systme and the serotoninergic system involved in acupuncture analge-sia was discussed.更多还原