【摘要】 <正> 促甲状腺激素释放激素(TRH)可作用于垂体前叶靶细胞的特异受体,激活腺苷酸环化酶一环磷酸腺苷系统,促进促甲状腺激素(TSH)的合成与释放。近年来,国内外常以TRH兴奋试验检验垂体TSH的贮更多还原

【Abstract】 Different doses of TRH were administered by I.V. injections to 26 normal subjects in order to observe their pituitary TSH reserve. Standardized TRH-stimulating test was performed in 42 patients. The chief results were as follows: 1. The method of I.V. injection of TRH is simple and the results are reliable. 2. The suitable dose for TRH injection is 2-8 μg/kg body weight, and the most appropriate dose for adult is 100-300μg. 3. The pituitary TSH response to TRH is independent of sex, but it shows-that the response decreases along with the increase of age. 4. The peak level of TSH occured at 15-30 minutes after the injection of TRH, so it is necessary to take the blood samples at three different time intervals: (1) Before injection of TRH (basal TSH level); (2)30 minutes after the injection (peak level); (3)60 minutes after injection. 5. Based on the value and the time of occurrence of the TSH peak level the results of the TRH stimulating tests may be divided into 5 categories: (1) Normal response or the control-the response of normal subjects: (2) Supernormal respons, primary hypothyroidism; (3) Subnormal response-secondary hypothyroidism; (4) Delayed response-hypothalamic syndrome; (5) No response-hyperthyroidism. This test can be applied to the basic and clinical studies in determining the functions of the hypothalamus-pituitary-thyroid axis, and it will give much help to the diffrential diagnosis of various kinds of hypothyroidism.更多还原