【摘要】 本文报道应用放射免疫法测定106例先天性心脏病、心肌病及心律失常患儿血清地高辛浓度,其中全程维持量组(19例)为1.11±0.6毫微克/毫升,饱和量组(15例)为1.22±0.72毫微克/毫升,两组比较无显著差异(P>0.05)。长期维持量组(30例)为0.78±0.47毫微克/毫升。中毒组(3例)为4.65～5.3毫微克/毫升。结合临床观察,全程维持量组患儿的心衰症状亦有明显改善,提示对慢性心衰患儿可不必用饱和量,只要用全程维持量同样有效且安全。但在本组中未用地高辛组89例患儿中有15例测出地高辛,浓度为0.1～0.55毫微克/毫升,所以在评价地高辛血清浓度时要注意非特异性凝集影响的可能.更多还原

【Abstract】 Serum digoxin concentration was measured(RIA)in 106 patients with congenitalheart disease,cardiomyopathy or cardiac arrhythmias,6—8 days after administrationof the maintenance dose of digoxin.When without the loading dose(19 cases),serum concen-tration was 1.11±0.6 ng/ml,and in group with loading dose(15 cases)it was 1.22±0.72ng/ml.There was no significant difference between the two(p>0.05).The symptomsof heart failure were also improved in the first group.This suggested that the“loadingdose”of digoxin is not necessary for patients with chronic heart failure.The averageserum digoxin concentration in 30 cases receiving digoxin for 1mo-11yr was 0.78±0.47ng/ml.In 3 intoxicated cases,the concentration was 4.65—5.3 ng/ml.In 39 casesdigoxin was never administered,digoxin could be detected in 15 at the level of 0.1—0.55 ng/ml.The possibility of non-specific coagulation should be considered in evaluatingserum digoxin concentration.更多还原