【摘要】 <正> 1970年以来临床上治疗子宫颈癌所采用的鲜天南星系产于河南许昌及安徽亳县。后经我院药学系中草药教研室等有关单位在原产地调查,确定是掌叶半夏(Pinellia peedatisecta Schott),几种剂型制备及化学成分分离已报道。经分析发现乙醇提取物中含有甾醇类物质。1975年将此物浓缩去醇,加水沉淀,在沉淀中分离出一种无色晶体,后经鉴定为β-谷甾醇。更多还原

【Abstract】 From the alcohol extract of Pinellia pedatisecta Sohott, another antitumor principle was obtained by saponification with alcoholic potassium hydroxide and fractionated on Al2O3 and silica gel columns. The structure of the purified antitumor principle was identified to be β-sitosterol by infrared spectra and comparable with an authentic β-sitosterol. The elementary analytic data of this antitumor principle and its benzoic ester were almost the same as those calculated from β-sitosterol and β-sitosterol-3-benzoate respectively. Hemisuooinate of β-sitosterol examined experimentally exhibited a marked inhibiting action on mouse sarcoma-180 when given orally. In order to observe the clinical therapeutic value against carcinoma of cervix, cervical suppositories of β-sitosterol, in the shape of plateform or of rodform were prepared with the use of polyethylene glycol MW-6000 as base. 56 oases of cervical squamous epithelial carcinoma, proved microscopically were treated with above suppositories. The results were as follows: short-term cure in 11 oases, marked improvement, 15 oases, some benefit, 16 oases and insensitive, 14 oases. Therapeutic efficacy as a whole was 75%. The mechanism of the antitumor action of the principle and its clinical value require further studies.更多还原