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何首乌中二苯乙烯甙的分离与鉴定

ISOLATION AND IDENTIFICATION OF STILBENE GLYCOSIDE FROM POL YGONUM MUL TIFLORUM THUNB

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【作者】 严秀珍;

【Author】 YAN XIU-ZHEN(Department of Chemistry of Natural Drugs, Shanghai First Medical College, Shanghai)

【机构】 上海第一医学院天然药物化学教学研究室;

【摘要】 <正> 何首乌系蓼科植物Polygonum multiflorum Thumb.的根和根茎,性能为通便解毒。制首乌补肝肾益精血,用作强壮剂和缓下剂。此外,对降低胆固醇具有一定的疗效。首乌水煎剂,以15克生药/公斤的剂量,有明显地降低大鼠血清总胆固醇的作用。临床试用首乌片剂,降胆固醇有效率为62.3%。因此,我们将首乌作系统提取分离,尤其对水溶性部分进行了分离与鉴定。

【Abstract】 Emodin, physion and β-sitosterol were isolated from the ether-soluble fraction of the alcoholic extract of rhizome of Polygonum multiflorum Thunb. A stilbene gly-coside was found in the water-soluble fraction and its acetyl derivative was prepared. The structure of the stilbene glycoside was identified through its acetate by chemical and spectroscopic methods (IB, NME, MS), as 2, 3, 5, 4’-tetrahydroxystilbene 2-0-β-D-glucoside.

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