【摘要】 15例成年奶牛按丹麦Bendixen氏检索表血液学检查结果:白血病阳性牛10例,可疑牛15例。11例(阳性—8,可疑—3)在33个部位发见眼观肿瘤。以真胃最多见(5/11),其次为子宫,网膜(3/11)。 对15例进行病理组织学检查,其中12例可诊断为淋巴肉瘤,包括一例肉眼未见肿瘤变化,而血像检查为阳性牛。淋巴样肿瘤细胞广泛地分布,在眼观未见肿瘤的器官,如脊髓、肾、脾、肝、小肠、心、肺等都可发现有不同程度的瘤细胞浸润和增生。 肿瘤由分化程度不等的未成熟淋巴细胞构成,可分为有包膜型和无包膜型两类。有包膜肿瘤中心坏死,在包膜中和包膜下可见到淋巴样瘤细胞浸润。 构成肿瘤的细胞类型可分为两种:一种貌似小淋巴细胞;另一种较大,似成淋巴细胞。 电镜观察病牛血液淋巴细胞,并做1例病牛血液淋巴细胞的染色体检查。更多还原

【Abstract】 A histopathologic study of bovine leukemia was carried out in 15 cows, of which 10 were haematologically positive and 5 were suspected according to Bendixens key. Macroscopic tumors were found at 88 locations in 11 eases——positive-8, suspected-3. The abomasum was the most susceptible organ (5/11),and the next were the uterus and the omenta (3/11).12 cases were diagnosed as lymphosarcomas by histopathologic examination, including 1 case without any macroscopic neoplastic change. Lymphoid neoplastic cells were found widespread in various organs, including the spinal cord,kidney, spleen, liver, intestine, heart and lung, although some of these organs might be normal in appearance.The tumors were divided into two kinds: encapsulated and non-encapsulated. Lymphoid cell infiltration was found in or under the capsule of the encapsulated tumor with a necrotic centre.The lymphosarcoma was composed of premature lymphocytes at different stages of differentiation. Generally, neoplastic cells were of two types: one was small lymphoid cells resembling lymphocytes, and the other larger, resemblingBlood lymphocytes were examined under an electronic microscope and the chromosmes of the lymphocytes were demonstrated in 1 case.更多还原