【摘要】 <正> 随着免疫学研究的进展,对结核病免疫的机制有了进一步认识。近年来从各方面研究结果认为结核病的免疫属于细胞免疫。关于儿童结核病人的免疫状态,国内尚未见报道。为此自79年3月～81年6月对在我院儿科结核病专科门诊及住院患儿共80名分别作三项体外法细胞免疫功能测定,现将所测结果报告如下。更多还原

【Abstract】 Cell-mediated immune response was studied in the following 80 cases:(1)28 cases of tuberculous infection(children with positive tuberculin test,andsymptoms of low grade fe0ver,anorexia,Weight loss,and easy fatigability but chest ro-entgenograms negative);(2)41 cases of active primary tuberculosis,of whom all hadpositive chest roentgenograms;(3)9 cases of tuberculous meningitis;(4)2 cases of acutemiliary tuberculosis.The results of E rosette formation assay and nonspecific lymph-ocyte transformation were shown in Table 1 and 2:(1)There was a significant decre-ase in percentage of Ea and Et,and lymphocyte transformation in patients of activeprimary tuberculosis(P<0.001),while cases of tuberculous infection had only slightdegree of cell-mediated imnune response abnormality,in which there was only signifi-cant decrease in lymphocyte transformation(P<0.01),but no significant difference inpercentage of Ea and Et,as compared with mean value of normal control.(2) patientswith tuberculous meningitis only showed a significant deccease in lymphocyte transf-ormation(P<0.001),but no significant differences in percentage of Ea and Et(P>0.05).2 cases of acute miliary tuberculosis had decrease in percentage of Ea,Et and lymp-hocyte transfomation,but further investigation was needed.(3)The follow-up study of21 patients of active primary tuberculosis showed a reversal of the immunologic ab-normalities to normal concomitant with clinical improvement on combined therapywith killed BCG and antituberculous treatment.Therefore,abnormalities appeared robea result of,rather than cause of the illness.更多还原