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胸腺瘤伴发纯红细胞再生障碍性贫血一例报告

PURE RED CELL APLASIA ASSOCIATED WITH THYMOMA,A CASE REPORT

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【作者】 苏学章凌柱三沈泽霜

【Author】 Su Xuezhung;Ling Zhusan;Shen Zeshuang Department of Medicine,The Second Affiliated Hospital,Hunan Medical College

【机构】 湖南医学院第二附属医院内科血液组湖南医学院第二附属医院内科血液组

【摘要】 <正> 纯红细胞再生障碍性贫血(以下简称纯红再障)是指仅累及红细胞系生成而不影响粒细胞和血小板的贫血。此类贫血较少见。胸腺瘤伴发纯红再障在国外文献虽有报道,但国内仅有2例报道,我们遇见1例,报道如下。盛×,男,33岁,社员,1979年10月10日入院。入院前三个月开始头昏,心悸,面色苍白,逐日加重。病后无出血倾向。入院前一天有感冒发烧。既往体健。1971年出现双眼皮下垂,吞咽无力,诊断为重症肌无力,服新斯的明即有好转,持续治疗四个月后症状消失。当时有无胸腺瘤不明。家族中无类似病史。

【Abstract】 A 33-year-old male farmer was admitted on Oct.10th,1979.In 1971 the patienthad symptoms of myasthenia gravis which subsided a few months later afterneostigmine treatment.No thymoma was noticed at that time.Three months priorto the present admission,the patient suffered from a progressive anemia.Chest filmrevealed enlargement of the thymus to both sides.Hemoglobin 4g%.RBC 1,200,000/cmm.Reticulocyte count 0.1%.WBC and platelets normal.Bone marrow aspiration disclos-ed marked erythroblastic aplasia with normal leucocytic series and megakaryocytes.There was a moderate increase of IgM to 258.3mg%.The patient was successivelytreated with repeated transfusions,thymusectomy,corticosteroid,androgen andimmunosuppressives for 6 months yet without any improvement.The pathogenesis ofthe syndrome and its relation to immunology were briefly discussed.

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