【摘要】 <正> 我省为恶性肿瘤鼻咽癌高发区之一,近年来国内外一些学者证明 EB 病毒与鼻咽癌的关系十分密切,特别是 EB 病毒壳抗原的免疫球蛋白 A(VCA-IgA)抗体,对鼻咽癌具有特异性。过去我组曾应用免疫荧光法检测鼻咽癌病人血清中的 VCA-IgA 抗体,阳性率为88.5%,头颈部其他肿瘤、鼻咽粘膜慢性炎症及正常人血清中的抗体阳性率低或为阴性,我们建立的免更多还原

【Abstract】 A total of 809 samples of sera,including 204 from untreated NPC patients,85 from treated NPC patients,33 from patients with other malignant tumors ofthe head and neck,105 from patients with other diseases of the head and neck and328 from normal subjects,were tested for EB virus-specific IgA antibody to VCAby immunoenzymie method.The frequencies of positive results in untreated andtreated NPC patients were 92.2% and 88.9%,with a GMT of 1:57.11 and 1∶20.81respectively,where as no significant titer of such antibody was found in the otherthree groups.These results indicate that the presence of IgA antibody to EBV-VCAin sera appears specific for patients with nasopharyngeal carcinoma.Thus,detectionof IgA antibody to VCA might be helpful in the diagnosis of nasopharyngealcarcinoma.更多还原