【摘要】 <正> Creutzfeldt-Jakob 氏病一般又称为亚急性脑海绵状变性。自1920年 Creutzfeldt 及1921年Jakob 报道以后又陆续有过报道。此病颇为罕见,临床诊断困难,最终往往死亡。在1955年以后开始有少数患者在生前经脑组织活检作出诊断。1968年 Gibbs 等发现用患者的脑组织混悬液接种于黑猩猩可使之出现相似的临床及病理表现。此后有不少证据提示此病是由更多还原

【Abstract】 The author reported a case suffered from Creutzfeldt-Jakob disease.In China,this is the first case diagnosed during the patien’s illness and confirmed by brainbiopsy afterward.In order to make an early diagnosis and give the patient a tentative antivirustreatment during his fatal process,the author recommeded a useful method of classi-fication according to some clinical pictures based on the facility of differentialdiagnosis.Clinical pictures are classified into four types:type 1(dementia and other corticalsigns),type 2(dementia and other cortical signs+extrapyramidal signs),type 3(de-mentia and other cortical signs+lower motor neurons muscular atrophy),type 4(dementia and other cortical signs+extrapyramidal signs+lower motor neuronsmuscular atrophy).Only a few diseases must be differentiated from Creutzfeldt-Jakobdisease in type 3 and type 4.Clinical pictures of the present case are consistentwith those of type 4.更多还原