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关于 XR 抗原研究的初步报告

A PRELIMINARY REPORT ON THE XR ANTIGEN STUDY

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【作者】 苏先狮王立庄李安华陈一德彭隆祥杨守纯周继文陶其敏王金琪常伟红曾庆善

【Author】 Su Xianshi;Wang Lishuang;Li Anhua;Chen Yide;Yang Shouchun;Zhou Jiwen;Tao Qimin;Wang Jingi;Peng Longxiang;Zeng Qingshan Department of Infectious Disease,The Second Affiliated Hospital,Hunan Medical College

【机构】 湖南医学院第二附属医院传染科湖南医学院中心实验室电镜室解放军302医院免疫室北京医学院附属人民医院肝病研究组长沙市传染病院湖南医学院中心实验室电镜室

【摘要】 <正> 近年来国内外对 ArAl 和 XR 抗原的认识和研究不断取得一些进展。ArAl 抗原抗体系统是古田精市在 e 抗原抗体的检测中发现的一种与 e 抗原抗体有区别的存在于血清中的新抗原抗体系统。以后重复检查的结果,发现在某些肝病患者血清中,ArAl 抗原检出阳性率较高。国内安康等首先发现 XR 抗原,并证明它与 ArAl 抗原相似,其后剪象福等证实了这一发现。以上的作者们都提出该抗原可能与肝损伤有相关关系。我们在2490例各种肝病和非

【Abstract】 A clinical and fundamental study of a new serum antigen(XR antigen)wasperformed.The sera from 2490 patients or controls were tested for the presence ofthe antigen by immuno-diffusion test.It was detected with fulminant hepatitis,hepatic cancer and with hepatic cirrhosis.It was rarely detected in patients withnonhepatic diseases and control subjects.The XR antigen of the patient’s sera and liver specimen was firstly and succ-essfully obtained by serial purifying procedures as follows:Extracentrifugation,KBrdensity gradients,Zonal centrifugation.The physiochemical properties of XR antigen were studied with purified materi-als,XR antigen has a density of 1.096gm/cm~3.The particles of the purified XR-antigen were spherical in shape and variable insize about 10-70nm in diameter.

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