【摘要】 <正> 宫颈癌是我国妇科恶性肿瘤中最常见的一种肿瘤,但其病因至今仍不十分清楚。目前许多资料认为与性生活开展的早、频繁,以及配偶多有关,且多见于妓女而少见于尼姑。因此,提出了可能存在有通过性交传播的致癌因子。故有理由将阴部单纯疱疹病毒当着怀疑的对象。Naib 等早在1966年就报告在经细胞学检查发现过去或现在有阴部疱疹病毒感染的妇女中有15%的人有宫更多还原

【Abstract】 The inadence of cancer induction in single and repeated vaginocervical infections with genital HSV in mice has been studied.The results as following: During 60-390 days after 1st viral inoculation,7(7.5%)or 93 mice infected intravaginally and repeatedly with strain CC21 of human genital herpes simplex virus (HSV) and 5(3.6%)of 136 mice infected one time only intravaginally with the same virus developed cancers of the cervix and/or vagina.No cancer could be found in the reproductive tract of the controls. The results demonstrated again that cervical and/or vaginal carcinoma may be induced in mice infected with genital HSV. Significant differences in the rate of tumor formation in mice were observed between the group treated repeatedly with HSV ADD and the con- trol group,but not between the group treated for a single time and control. Thus repeated application of a viral inoculation was slightly more carcinog- enic than a single one. Two principal patho-histological types of lesions,namely adenoid car- cinoma and squamous cell carcinoma,were observed in this study.更多还原