【摘要】 <正> 一、前言 2,3-苯骈-1-硫-4-氮-5,7-二取代（或5,7,7-三取代）-4,5,6,7-四氢化硫氮杂（艹卓）（简称四氢化苯骈杂（艹卓））和6,7-二氢化硫氮杂（艹卓）（简称二氢化苯骈杂（艹卓））是治疗神经系统疾病的药物。我们对七个四氢化苯骈杂（艹卓）和六个二氢化苯骈杂（艹卓）进行核磁波谱研究。这类化合物的七元杂环内含有一个或二个不对称碳。手性碳的存在导致其相邻的-CH₂-上二个氢磁不等同,形成了原手性基团,使谱线裂分。通过双共振技术（同核去偶、INDOR）和计算机自旋模拟等技术着重研究七元杂更多还原

【Abstract】 The ~1H NMR assignments of seven tetrahydro-derivatives and six dihydro-derivatives of benzothiazepines have been made. With the aid of the techniques of proton-proton decoupling, INDOR, spin simulation programs, the applications of empirical additivity rules, Karplus equation, and the comparison of series of homologous compounds, the chemical shifts and coupling constants of various types of protons in the molecules and the orientation of certain groups in space have been determined. The nuclear magnetic non-equivalent phenomenon of the prochiral gem methylene protons has been discussed. The results are also discussed in terms of inductive, conjugative, shielding effects and long range coupling between fluorine and hydrogens.更多还原