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青羊参的中枢药理作用研究

CENTRAL PHARMACOLOGICAL ACTION OF CYNANCHUM OTOPHYLLUM SCHNIED

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【作者】 裴印权曹龙光谢淑娟蔡志基木全章

【Author】 Pei Yin-quin, Department of Pharmacology, Beijing Medical College

【机构】 北京医学院药理教研室北京垂杨柳医院云南植物研究所

【摘要】 <正> 青羊参(Cynanchum Otophyllum Schnied),又称青阳参、白石参、毒狗药等,是萝摩科(AS-C1 epiadaceae)鹅绒藤属(Cynachum Linn)的植物,产于云南海拔2400~2700米的山区。根茎入药,性味甘辛温,能补肾虚,治癫痫、头昏、心悸、小儿惊风和风湿性关节炎等。近来有人证明其氯仿提取物对

【Abstract】 The chloroform extract of C. Otophyllum Schnicd can protect rats from audiogcnic seizures, but not from seizures produced by electroshock, metrazol and strychnin, It can increase anticanvulsant action of diphenylhydantoin and phenobarbital when used in combination It also can depress the avoidance responses in mice.C. O. Schnied has no influence on ECoG of normal rabbits, when it is used intravenously in dosage of 12.5gm/kg, but when the dosage is incresed to 25 mg/kg, abnormal changs in ECoG can be seen in some rabbits, In dosage of 50 mg/kg, typical clonic seizures can be observed in some rabbits.This drug has therapeutic effects for the chronic experimental model of epilepsy, produced by intracerebral injection of ferrous sulfate, and can also normalize the abnormal changs in ECoG produced by ferrous sulfate.

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