【摘要】 <正> c-AMP和c-GMP是体内的第二信使。有资料表明吗啡的作用机制中很可能有环核苷酸参与。近年来关于针刺镇痛原理研究中发现,中枢c-AMP和c-GMP在针刺镇痛中也起着重要作用。我们曾经报告,给大鼠脑室注射c-AMP使针刺镇痛效果降低,注射c-GMP则可提高针刺镇痛作用。最近又观察到,针刺镇痛时全脑c-AMP含量明显下降。为了进一步研究中枢环核苷酸在针刺镇痛中的作用,本实验同时测定了大鼠全脑和脑分区中c-AMP和c-GMP的含量及其在电针后的变化,并对其机制进行了初步分析。更多还原

【Abstract】 123 rats weighing 150—200g were used for observation of the effcet of electroacupuncture on the brain concentration of cAMP and cGMP, as measured by protein binding and radioimmunoassay respectively. Electroacupuncture for 30 minutes brought about a 18% decrease of cAMP in whole brain and 32.5% decrase in the telencephalon. No significant change of cGMP content was found in the whole brain. However localization study revealed an 43% increase in lower brain stem and 25% decrease in diencephalon. All these statistically significant changes were reversed by intraventricular injection of naloxone, the specific opiate antagonist. The results indicated that the changes of central cAMP and cGMP concentrations in discrete brain areas may be attributed to the selective release of endogenous opiate-like substances induced by electroacupucture.更多还原