【摘要】 <正> 河南省南阳地区民间流传用燕山蛩治疗食管癌。《本草纲目》记载它“有大毒”,可“烧黑,傅恶疮”。我们在采风的基础上对它进行了动物实验,在实验中发现,它的提取物对小鼠某些移植性肿瘤生长有一定抑制作用,且毒性不大。现将结果报道如下。更多还原

【Abstract】 The antitumor effect of Spirobolus bun-gii extracts was studied in mice with soliduterocervical carcinoma(U₁₄),sarcoma₃₇(S₃₇),Lewis lung carcinoma（Lewis）andascites uterocervical carcinoma(U₁₄A),sar-coma₁₈₀ (S₁₈₀A),Ehrlich tumor（ECA）.The agents tested included water,ethanol,ether and ethanol-ether extracts.All extractswere administered in solid tumor-bearingmice intraperitoneally for 12—14 days andascites tumor-bearing mice for 4—8 days.The optimal daily dose established for these4 extracts was 0.3,1.3,0.15—0.3 and 0.05—0.2 gm/kg respectively.The tumor growthinhibiting effect was determined for theseextracts in animal with U₁₄,Lewis and U₁₄A,S₁₈₀A,ECA;it ranged from 28.2 to 59.8%in solid tumor and from 72.8 to more than95% in ascites,but water extract showed noinhibiting effect on growth.Treating theanimal with U₁₄by ethanol-ether（0.2gm/kgdaily for one,six and nine days）,the ratioof survival time as compared with the con-trol group was 155,163 and 207% respecti-vely.The toxic tests of ethanol-ether ex-tract showed that its safety coefficient wasmore than 10,and there was no obvious har-mful effect on the heart,lung,spleen,kid-ney except a slight hepatatrophic effect inmice with 0.1—0.4gm/kg/day dose for 26days.更多还原