【摘要】 <正> 黄苠是中医常用的补气药,具有降压、利尿、抗肾炎、护肝、提高免疫功能等多方面的作用,有关黄芪的降压作用及共原理已有报道,并认为黄芪的降压作用主要是外周作用,这一作用与胆碱能系统及组织胺的释放无关。关于黄芪的化学成分也有报道,但其降压成分尚未查明,仅 Hikino 等报告认为黄芪降压作用的主要成分为γ-氨酪酸(GABA),并提出测定 GABA 的含量可作为判断不同产地黄芪质量好坏的一个指标。本文根据实验结果就黄芪的外周作用是否为直接扩血管作用加以探讨,并在此基础上,比较我国几个不同产地黄芪的作用及其与 GABA 含量的关系。更多还原

【Abstract】 Experiments were performed on anes-thetized dogs.The vascular resistance of hindlimb was determined by means of constantflow perfusion technique and systemic arte-rial blood pressure was recorded concomitan-tly.An extract from the roots of huang-qiwas injected intravenously or intra-arteriallyin comparison with GABA.The generaof huang-qi of different habitat used in theexperiments were identified as:“Shan-xihuang-qi”and“Gan-su huang-qi”——theroots of Astragalus mongholicus Bunge,“Shan- dong huang-qi”——A.membranaceus(Fisch.)Bunge.Results show that intravenous injec-tion of huang-qi at a dosage of 1.0 gm.perkg.(in terms of the weight of crude drug)causes marked decrease of systemic blood pre-ssure and vascular resistance of hind limb.This effect is considered as a result of di-rect peripheral vasodilatation action and isindependent of its action on the heart.Ascompared with huang-qi,GABA injectedintravenously at a dosage of 10 mg.per kg.(approximated to 30 times of GABA contentin the roots of huang-qi)causes a similarvascular effects,but intra-arterial injectionof small amount of huang-qi(1/25 of in-travenous dose)causes a marked decrease ofvascular resistance of hind limb while GABAdoes not.It seems that GABA cannot repre-sent huang-qi as a whole in respect to itsvascular effect.Results also show that thereare marked difference in the potency of vas-cular action of huang-qi of different habi-tat,but it seems to be no parallel correlationbetween their potency and the content ofGABA.更多还原