【摘要】 <正> 青蒿素为从菊科植物黄花蒿(Artemisia annua L.)中分得的具有过氧键的新型倍半萜内酯,其结构经X线衍射,化学方法及各种光谱数据的分析证明为(Ⅰ)。大量动物实验和临床观察证明青蒿素为一高效、速效、低毒的抗疟新药。为了给临床提供合理的用药依据,搞清其生物体内的代谢转化及其转化物的生理活性供新药设计时参考,我们对疟疾病人及正常人更多还原

【Abstract】 From human urine, following oral administration of the drug to malaria patients, three metabolites (Ⅱ), (Ⅳ) and (Ⅴ) were isolated and identified. The metabolites were all inactive against rat malaria.更多还原