【摘要】 <正> 毛叶轮环藤[Cyclea barbata(Wall)Miers]为防己科轮环藤属植物,在海南岛有野生。其根俗称“银不换”。主治喉炎、腹痛及牙痛,并用于跌打损伤。中国人民解放军第一八七医院首先发现并经临床试验,证明其总生物碱的碘甲烷盐,具有明显的横纹肌松弛作用。 国外,从该植物中,已分得十二种生物碱。本文报道从“银不换”的总生物碱中,除分得更多还原

【Abstract】 Five alkaloids have been isolated from the roots of Cyclea barbata （Wall.） Miers （Menispermaceae） grown in Hai-nan island, China. Four of them are identified to be d-tetrandrine （the main alkaloid）, homoaromoline, l-curine and d-isochondodendrine. Alkaloid Ⅴ is not yet identified. The test for neuromuscular blocking activity of the dimethiodide derivatives of these alkaloids showed that l-curine 2 CH₃I was more powerful than the other four and belonged to a nondepolarizing type.The neuromuscular blocking activity of dimethyl-l-curinedimethochloride was found to be about 4 times as powerful as l-curine. dimethiodide The water solubility of the former was 250～300 times higher than that of dimethyl-l-curine-dimethiodide.The clinical tests of l-curine dimethiodide and dimethyl-l-curine dimethochloride on 210 and 412 cases respectively have been completed. The effects of the former approximate to that of α-tubocurarine, while for the latter, satisfactory results of all cases were obtained.更多还原