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放射病预防药物的研究——Ⅰ.若干硫代吗啉的巯基和氨基衍生物的合成

STUDY OF ANTIRADIATION DRUGS I Synthesis of Some Mercapto and Amino Derivatives of Thiomorphgline

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【作者】 陈福祥吴益芝朱应麒李志毅

【Author】 Chen Fuxiang, Wu Yizhi, Zhu Yingqi and Li Zhiyi (Shanghai Institute of Material Medica, Academia Sinica)

【机构】 中国科学院上海药物研究所中国科学院上海药物研究所中国科学院上海药物研究所 江西省黎明药厂

【摘要】 本文报道2-取代硫代吗啉的氨乙基Ⅺ、氨丙基Ⅻ和相应的巯基衍生物Ⅸ及磺原酸类Ⅹ的合成。初步进行小白鼠急性放射病的防护试验。

【Abstract】 Although a variety of organic compounds bearing thiomorpholine ring system possess many interesting pharmacological properties, simplier derivatives carrying this ring system have scarcely been investigated in the field of drug research. In our preliminary. study of antiradiation drugsi it has been shown that-β-mercaptoethylamine, Ⅵ, and some simple amino derivatives Ⅶ and Ⅷ exhibited prophylactic activities against ionization radiation. These results gave us an impetus to study whether thiomorpholine (which may be regarded as the cyclic ether of mercatoethylamine) or its derivatives related to Ⅵ, Ⅶ and Ⅷ would show promise as antiradiation drugs.In the present paper the synthesis of a series of mercaptoethylamine derivatives carrying thiomorpholine moiety Ⅸ, some xanthates Ⅹ and amino derivatives of Ⅺ, Ⅻ related to Ⅶ and Ⅷ was reported.

  • 【文献出处】 药学学报 ,Acta Pharmaceutica Sinica , 编辑部邮箱 ,1980年08期
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