S72014 is a derivative of niridazole. It has been found that the therapeutic index of S72014 to mice was 21.2, while that of niridazole was 5.8. When rabbits infected with schistostomes were treated orally with S72014 at the dosage of 200 mg/kg/day for 2～3 days, or 50～70 mg/kg/day, for 10～14 days, the worm reduction rates were higher than 90%, with part of the animals completely cured. After its administration to infected dogs at the dosage of 41.7 or 66.7 mg/kg thrice daily for 7 days, all the animals were...
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