【摘要】 <正> 我所1975年合成的茚满类化合物中,发现S75029(4-溴-7-羟基茚满肟,Ⅰ)具有抗血吸虫作用,乃对其疗效与毒性进行了一些观察。更多还原

【Abstract】 S75029 （indane oxime） is a new type of antischistosomal drug. When administered orally to mice, rabbits or dogs infected with Schistosoma Japonicum, some vermicidal effect was observed. But even at maximum tolerated dosage in a 3～20 day course, the worm reduction rate was only about 40%. After its administration to mice at the dosage of 1/2～2/3 LD₅₀ for 7 or 10 days, different degree of pathological changes were observed in stomach, intestine and kidney. All these tissue lesions disappeared one month after the cessation of treatment.更多还原