【摘要】 <正> 在口服(或其他静脉外途径,下同)给药的情况下,多数药物的体内过程显示一室开放形模型(图1)的特征,计算所给药物未经变化而到达体循环的速率——吸收速率(一般用一级速率常数K_α表征),最常用的方法是Wagne-Nelson法。更多还原

【Abstract】 For one-compartment open model, an equation for computing drug absorption rate constant (k_a) is described [equation (9) in the text]. The derivation of the equation is independent of the Wagner-Nelson equation. However, the computational procedure of the k_a is similar to the Wagner-Nelson method, the accuracy, is the same, but the computation is simpler.更多还原